The impact of parkinsonism on costs of care in patients with AD and dementia with Lewy bodies

作者: D. L. Murman , S. B. Kuo , M. C. Powell , C. C. Colenda

DOI: 10.1212/WNL.61.7.944

关键词:

摘要: Objective: To compare the annual direct costs for patients with Alzheimer’s disease (AD) and no parkinsonism (AD), AD (AD/P), dementia Lewy bodies (DLB). For entire sample, authors examined incremental associated increasing parkinsonism. Methods: Cross-sectional comparisons of 1 year were done. Fifteen met criteria DLB, 133 probable AD, whom 39 had signs 94 did not. Patients’ caregivers reported on patient’s use health care services, receipt unpaid care, comorbid medical conditions. Severity cognitive impairment determined during patient examinations. Costs estimated by multiplying utilization data a unit cost each type care. compared after adjustment covariates using multiple regression equations. Results: After adjusting important covariates, AD/P or DLB significantly higher than AD. The average adjusted increases in above baseline $7,119 (AD/P) $13,754 (DLB) formal $7,394 $19,564 total costs. Models sample that 1-point increase scale would result an $784 $827 Conclusions: Patients have disease. Signs degenerative dementias are significant independent predictors

参考文章(24)
Michael P. Caligiuri, Dilip V. Jeste, Jonathan P. Lacro, Antipsychotic-Induced movement disorders in the elderly: epidemiology and treatment recommendations. Drugs & Aging. ,vol. 17, pp. 363- 384 ,(2000) , 10.2165/00002512-200017050-00004
Elizabeth C. Clipp, Michael J. Moore, Caregiver time use: An outcome measure in clinical trial research on Alzheimer's disease Clinical Pharmacology & Therapeutics. ,vol. 58, pp. 228- 236 ,(1995) , 10.1016/0009-9236(95)90201-5
J. M. Olichney, D. Galasko, D. P. Salmon, C. R. Hofstetter, L. A. Hansen, R. Katzman, L. J. Thal, Cognitive decline is faster in Lewy body variant than in Alzheimer's disease Neurology. ,vol. 51, pp. 351- 357 ,(1998) , 10.1212/WNL.51.2.351
Y. Stern, M. Albert, J. Brandt, D. M. Jacobs, M-X Tang, K. Marder, K. Bell, M. Sano, D. P. Devanand, F. Bylsma, G. Lafleche, Utility of extrapyramidal signs and psychosis as predictors of cognitive and functional decline, nursing home admission, and death in Alzheimer's disease: Prospective analyses from the Predictors Study Neurology. ,vol. 44, pp. 2300- 2307 ,(1994) , 10.1212/WNL.44.12.2300
M. Richards, K. Marder, K. Bell, G. Dooneief, R. Mayeux, Y. Stern, Interrater reliability of extrapyramidal signs in a group assessed for dementia. JAMA Neurology. ,vol. 48, pp. 1147- 1149 ,(1991) , 10.1001/ARCHNEUR.1991.00530230055021
Ira R. Katz, Dilip V. Jeste, Jacobo E. Mintzer, Christopher Clyde, Judy Napolitano, Martin Brecher, , Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial. Risperidone Study Group. The Journal of Clinical Psychiatry. ,vol. 60, pp. 107- 115 ,(1999) , 10.4088/JCP.V60N0207
D.L. Murman, Q. Chen, M.C. Powell, S.B. Kuo, C.J. Bradley, C.C. Colenda, The incremental direct costs associated with behavioral symptoms in AD. Neurology. ,vol. 59, pp. 1721- 1729 ,(2002) , 10.1212/01.WNL.0000036904.73393.E4
Patricia A. Parmelee, Paul D. Thuras, Ira R. Katz, M. Powell Lawton, Validation of the Cumulative Illness Rating Scale in a geriatric residential population Journal of the American Geriatrics Society. ,vol. 43, pp. 130- 137 ,(1995) , 10.1111/J.1532-5415.1995.TB06377.X
Willard G. Manning, The logged dependent variable, heteroscedasticity, and the retransformation problem Journal of Health Economics. ,vol. 17, pp. 283- 295 ,(1998) , 10.1016/S0167-6296(98)00025-3