Physiological Regulation of Prostaglandins in the Kidney

摘要: Cyclooxygenase-derived prostanoids exert complex and diverse functions within the kidney. The biological effect of each prostanoid is controlled at multiple levels, including (a) enzymatic reactions catalyzed sequentially by cyclooxygenase synthase for synthesis bioactive (b) interaction with its receptors that mediate functions. act in an autocrine or a paracrine fashion can serve as physiological buffers, protecting kidney from excessive functional changes during stress. Through these actions, play important roles maintaining renal function, body fluid homeostasis, blood pressure. Renal cortical COX2-derived prostanoids, particularly PGI2 PGE2, critical pressure function volume-contracted states. medullary appear to have antihypertensive individuals challenged high-salt diet. Loss EP2 IP receptor associated salt-sensitive hypertension. COX2 also plays role interstitial cell viability hypertonic environment medulla. are involved certain pathological processes. participates pathogenesis vascular hypertension through stimulating renin release. COX-derived be diabetic nephropathy. COXs, synthases, should provide fruitful targets intervention pharmacological treatment disease.