High prevalence of hepatitis C virus genotype 6 among certain risk groups in Hong Kong
作者： Derek A. Wong , Louis K. Tong , Wilina Lim
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摘要: The genotype of hepatitis C virus (HCV) 172 HCV-RNA positive serum specimens taken from patients with chronic liver diseases, thalassaemia major, renal failure (CRF), haemophilia and intravenous drug abusers (IVDA) was determined by analysis the amplified 5′UTR region genotype-specific oligonucleotide probes restriction fragment length polymorphism (RFLP). Six different genotypes subtypes (1a, 1b, 2, 3, 4 6) were found. Genotype 1b predominant among diseases (69.6%), followed 6 (18.8%), which similar to that reported for blood donors in earlier studies. Pronounced differences distribution seen between four risk groups. Patients CRF had a those whilst greatest diversity haemophilia, expected since they given factor VIII manufactured overseas. particularly prominent major (50%) IVDA (62.5%). It is possible clonal spread HCV has place closed subset population Hong Kong through abuse.
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