A rapidly evolving revolution in stem cell biology and medicine
作者： Alan Trounson
DOI: 10.1016/J.RBMO.2013.07.005
关键词:
摘要: The developments arising from human IVF are remarkable. Embryos were studied for developmental patterns that have consequences viability and fertility. Growing blastocysts in vitro allowed further exploration of the differentiation primitive embryonic cells, leading to discovery stem cells (ESC). availability perhaps unlimited num- bers ESC could inform study also provide therapies regenerative medicine. cell biology been impressive, including induced pluripotent - adult trans- duced by specific transcription factors behave like ESC. Key regulators development such as activators or inhibitors lineage progression explored, particularly fibroblast growth factor, Wnt transforming factor b sig- nalling pathways miRNA. Such can be utilized algorithms predict how differentiate vitro. Using multistep protocols, many different types formed matured into functionally effective some which already translational research clinical applications. Possible future include destruction cancer reversal type I diabetes, restoration vision, repair motor function, cure HIV/AIDS heart muscle regeneration. RBMOnline
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