Frontal Structural Neural Correlates of Working Memory Performance in Older Adults.

摘要: Working memory is an executive process that allows transitional information to be held and manipulated temporarily in stores before being forgotten or encoded into long-term memory. necessary for everyday decision-making problem solving, making it a fundamental the daily lives of older adults. relies heavily on frontal lobe structures known decline with age. The current study aimed determine neural correlates decreased working performance lobes by comparing cortical thickness surface area from two demographically matched groups healthy adults, free cognitive impairment, high versus low N-Back (N=56; average age = 70.29 ± 10.64). High-resolution structural T1-weighted images (1mm isotropic voxels) were obtained 3T Philips MRI scanner. When compared performers, performers exhibited significantly three regions lateralized right hemisphere: medial orbital gyrus, inferior superior gyrus (FDR p < 0.05). There no significant differences between groups, proxy neurodegenerative tissue loss. Our results suggest decreases (a brain integrity) may underlie age-related function.