Relationship between the 4Ts scoring system and the antiplatelet factor 4/heparin antibodies test in critically ill patients

摘要: Aim Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction and potentially progresses to fatal thrombosis. The 4Ts scoring system has been reported as a clinical pretest for HIT. However, its usefulness in critically ill patients not yet thoroughly examined. Thus, we evaluated the of score diagnosis HIT patients. Methods One hundred four who were admitted our intensive care unit underwent antiplatelet factor 4/heparin complex antibodies (PF4/heparin Ab) test with suspected enrolled study. primary endpoint variable was score. secondary variables laboratory data, length stay, mortality, compared between thePF4/heparin Ab positive negative groups. Results There no significant difference scores PF4/heparin groups. predictive value (HIT patients/4T high patients) 15.4% (2/13), (non-HIT low 87.5% (42/48), false-negative rate (4T patients/HIT 54.5% (6/11). had longer stay (P = 0.035). Conclusions The present study showed discrepancy Ab. When patients, immediate antibody initiation therapeutic management are required regardless