Ultrasmall Mixed Eu-Gd Oxide Nanoparticles for Multimodal Fluorescence and Magnetic Resonance Imaging of Passive Accumulation and Retention in TBI.

摘要: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBI can have long-term impact on the quality life for survivors all ages. However, there remains no approved treatment that improves outcomes following TBI, which partially due to poor delivery therapies into brain. Therefore, significant unmet need develop more effective strategies increase accumulation retention potentially efficacious treatments in injured Recent work has revealed nanoparticles (NPs) may offer promising approach site-specific delivery; however, detailed understanding specific NP properties promote are still being developed. Multimodal imaging plays vital role physicochemical initiate uptake NPs at both high spatial (e.g., fluorescence imaging) temporal magnetic resonance imaging, MRI) frequency. many systems currently used only provide contrast single modality limiting data be obtained, those multimodal capabilities complicated multistep synthesis methods. goal this was an ultrasmall with simple fabrication capable imaging. Here, we describe development, characterization, accumulation, poly(ethylene glycol) (PEG)-coated europium-gadolinium (Eu-Gd) mixed (MNPs) controlled cortical mouse model TBI. We find these having core size 2 nm small hydrodynamic 13.5 detected MR modalities rapidly accumulate retained parenchyma. These should allow further testing other disease models.