The epidermal growth factor family in the mammary gland and other target organs for ovarian steroids

摘要: The influence of ovarian steroids on the growth and development normal mammary gland tumors in laboratory rodents is well known to research investigator, has emphasized need understand pathways by which these compounds exert their effects target organs. clinical significance ovaries breast cancer was evident around turn century, when ovariectomy shown ameliorate course this disease some women [1]. high incidence United States marked reduction ovariectomized an early age suggest a permissive or promotional role for [2, 3, 4]. Similarly, at menarche menopause risk may be explained duration extent exposure [5]. long-term use estrogens relieve postmenopausal symptoms already been linked with increased endometrial carcinoma [6]. This exogenous natural synthetic antagonists purposes estrogen replacement therapy, contraception, treatment prevention become major health issue dilemma, especially we consider millions treated category drugs.