The activity of class I, II, III and IV alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in renal cell carcinoma
作者： Karolina Orywal , Wojciech Jelski , Tadeusz Werel , Maciej Szmitkowski
DOI: 10.1016/J.YEXMP.2015.03.012
关键词:
摘要: Abstract Objectives Ethanol has been considered as a lifestyle risk factor for cancer in humans. While some studies have indicated that alcohol intake preventive effect renal cell cancer, others not. The metabolism of cells may be many ways different than healthy tissue and its disturbances could associated with carcinogenesis. aim this study was to compare the normal by measurement ADH isoenzymes ALDH activities these tissues. Material methods material consisted 43 cancerous tissues (14 patients stage II, 19 III 10 IV). Class IV total were measured photometric method class I II fluorometric class-specific fluorogenic substrates. Results activity isoenzyme significantly higher every compared Analysis did not show statistically significant differences between cells. Conclusion increased especially ALDH, intensifying carcinogenesis because increasing ability highly carcinogenic acetaldehyde formation causing disorders biologically important substances.
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sci-hub.se 参考文章(35)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Tsunehiro, Oyama, Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism. Frontiers in Bioscience. ,vol. 10, pp. 951- 960 ,(2005) , 10.2741/1589
A. Catharine Ross, Reza Zolfaghari, Judith Weisz, Vitamin A: recent advances in the biotransformation, transport, and metabolism of retinoids Current Opinion in Gastroenterology. ,vol. 17, pp. 184- 192 ,(2001) , 10.1097/00001574-200103000-00015
Jacek Wierzchowski, Piotr Wroczynski, Katarzyna Laszuk, Elzbieta Interewicz, Fluorimetric Detection of Aldehyde Dehydrogenase Activity in Human Blood, Saliva, and Organ Biopsies and Kinetic Differentiation between Class I and Class III Isozymes Analytical Biochemistry. ,vol. 245, pp. 69- 78 ,(1997) , 10.1006/ABIO.1996.9921
L. Skurský, J. Kovář, Milada Štachová, A sensitive photometric assay for alcohol dehydrogenase activity in blood serum. Analytical Biochemistry. ,vol. 99, pp. 65- 71 ,(1979) , 10.1016/0003-2697(79)90044-7
Takeshi Haseba, Gregg Duester, Akio Shimizu, Isao Yamamoto, Kouji Kameyama, Youkichi Ohno, In vivo contribution of Class III alcohol dehydrogenase (ADH3) to alcohol metabolism through activation by cytoplasmic solution hydrophobicity. Biochimica et Biophysica Acta. ,vol. 1762, pp. 276- 283 ,(2006) , 10.1016/J.BBADIS.2005.11.008
Jacek Wierzchowski, Werner P. Dafeldecker, Barton Holmquist, Bert L. Vallee, Fluorometric assays for isozymes of human alcohol dehydrogenase. Analytical Biochemistry. ,vol. 178, pp. 57- 62 ,(1989) , 10.1016/0003-2697(89)90356-4
K Morimoto, T Takeshita, Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes. Environmental Health Perspectives. ,vol. 104, pp. 563- 567 ,(1996) , 10.1289/EHP.96104S3563
Kazufumi Dohmen, Enrique Baraona, Hiromi Ishibashi, Gabriele Pozzato, Michele Moretti, Chika Matsunaga, Kazuma Fujimoto, Charles S. Lieber, Ethnic differences in gastric sigma-alcohol dehydrogenase activity and ethanol first-pass metabolism Alcoholism: Clinical and Experimental Research. ,vol. 20, pp. 1569- 1576 ,(1996) , 10.1111/J.1530-0277.1996.TB01701.X
Jinfu Hu, Yang Mao, Marie DesMeules, Ilona Csizmadi, Christine Friedenreich, Les Mery, Canadian Cancer Registries Epidemiology Research Group, Total fluid and specific beverage intake and risk of renal cell carcinoma in Canada. Cancer Epidemiology. ,vol. 33, pp. 355- 362 ,(2009) , 10.1016/J.CANEP.2009.10.004