Renal Function as a Predictor of Outcome in a Broad Spectrum of Patients With Heart Failure

摘要: Background— Decreased renal function has been found to be an independent risk factor for cardiovascular outcomes in patients with chronic heart failure (CHF) markedly reduced left ventricular ejection fraction (LVEF). The aim of this analysis was evaluate the prognostic importance a broader spectrum CHF. Methods and Results— Candesartan Heart Failure:Assessment Reduction Mortality Morbidity (CHARM) program consisted three component trials that enrolled symptomatic CHF, based on use ACE inhibitors (≤40%) or preserved LVEF (>40%). Entry baseline creatinine required below 3.0 mg/dL (265 μmol/L). Routine serum assessments were done 2680 North American patients. An estimated glomerular filtration rate (eGFR), using Modification Diet Renal Disease equation death hospitalization failure, as well all-cause mo...