Neuropeptide Y receptor in the rat brain.
作者： Anders UNDEN , Kazuhiko TATEMOTO , Viktor MUTT , Tamas BARTFAI
DOI: 10.1111/J.1432-1033.1984.TB08588.X
关键词:
摘要: The specific binding of the chloramine-T iodinated neuropeptide Y (125I-NPY) to membranes from rat cerebral cortex was investigated using equilibrium and kinetic methods. 125I-NPY at 37°C characterized by a Kd value 0.38 nM. receptor densities in cortex, hypothalamus cerebellum were 0.45 pmol/mg, 0.47 pmol/mg 0.04 protein respectively. site for sensitive treatment with proteolytic enzymes thiol reagents. showed sharp optimum pH 7 - 7.7 inhibited increasing concentrations Mg2+
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