Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity.

摘要: Attenuated growth hormone and insulin-like factor-1 (GH/IGF-1) signaling is associated with extended lifespan in several animal models. However, the effect of diminished GH/IGF-1 activity on survival humans has not been confirmed. We tested hypothesis that IGF-1 levels nonagenarians (n = 184), measured at study enrollment, predict duration their incremental survival. In Kaplan–Meier analysis, females below median (≤ 96 ng mL−1) had significantly longer compared above median, P < 0.01. this advantage was observed males (P 0.83). On other hand, both a history cancer, lower predicted 0.01). level remained significant predictor linear regression models after multivariable adjustment 0.01) individuals cancer show for first time low life expectancy exceptionally long-lived individuals.