Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis
作者： A. S. Brack , M. J. Conboy , S. Roy , M. Lee , C. J. Kuo
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摘要: The regenerative potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis. We show that muscle stem cells (satellite cells) from …
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Geoffrey Goldspink, Kenneth Fernandes, Pamela E. Williams, Dominic J. Wells, Age-related changes in collagen gene expression in the muscles of mdx dystrophic and normal mice Neuromuscular Disorders. ,vol. 4, pp. 183- 191 ,(1994) , 10.1016/0960-8966(94)90019-1
F. Kuhnert, C. R. Davis, H.-T. Wang, P. Chu, M. Lee, J. Yuan, R. Nusse, C. J. Kuo, Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 266- 271 ,(2004) , 10.1073/PNAS.2536800100
H. Liu, M. M Fergusson, R. M. Castilho, J. Liu, L. Cao, J. Chen, D. Malide, I. I. Rovira, D. Schimel, C. J. Kuo, J. S. Gutkind, P. M. Hwang, T. Finkel, Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging Science. ,vol. 317, pp. 803- 806 ,(2007) , 10.1126/SCIENCE.1143578
Thilo Hagen, Elena Di Daniel, Ainsley A. Culbert, Alastair D. Reith, Expression and Characterization of GSK-3 Mutants and Their Effect on β-Catenin Phosphorylation in Intact Cells Journal of Biological Chemistry. ,vol. 277, pp. 23330- 23335 ,(2002) , 10.1074/JBC.M201364200
Karl Willert, Roel Nusse, β-catenin: a key mediator of Wnt signaling Current Opinion in Genetics & Development. ,vol. 8, pp. 95- 102 ,(1998) , 10.1016/S0959-437X(98)80068-3
Irina M. Conboy, Michael J. Conboy, Amy J. Wagers, Eric R. Girma, Irving L. Weissman, Thomas A. Rando, Rejuvenation of aged progenitor cells by exposure to a young systemic environment Nature. ,vol. 433, pp. 760- 764 ,(2005) , 10.1038/NATURE03260
Irina M. Conboy, Thomas A. Rando, Aging, Stem Cells and Tissue Regeneration: Lessons from Muscle Cell Cycle. ,vol. 4, pp. 407- 410 ,(2005) , 10.4161/CC.4.3.1518
Roel NUSSE, Wnt signaling in disease and in development Cell Research. ,vol. 15, pp. 28- 32 ,(2005) , 10.1038/SJ.CR.7290260
Marco Chilosi, Venerino Poletti, Alberto Zamò, Maurizio Lestani, Licia Montagna, Paola Piccoli, Serena Pedron, Manuela Bertaso, Aldo Scarpa, Bruno Murer, Alessandra Cancellieri, Roberta Maestro, Gianpietro Semenzato, Claudio Doglioni, Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis American Journal of Pathology. ,vol. 162, pp. 1495- 1502 ,(2003) , 10.1016/S0002-9440(10)64282-4
Christian Pastoret, Alain Sebille, mdx mice show progressive weakness and muscle deterioration with age Journal of the Neurological Sciences. ,vol. 129, pp. 97- 105 ,(1995) , 10.1016/0022-510X(94)00276-T