Proteolysis in Neuropeptide Processing and Other Neural Functions

摘要: Proteolysis is commonly associated with degradation, inactivation, and turn­ over of peptides proteins in cells (Goldberg & St. John 1976, Lajtha Dunlop 1978 , Hershko Ciechanover 1981). However, it also plays a more subtle role the "functional modification" protein substrates, through limited proteoiysis (Holzer Heinrich 1980, Reich et aI1975). In recent years has become increasingly apparent that presence biologically active tissues function not only biosynthet­ ic mechanism per se but variety postsynthetic (i.e. post­ translation�l) processing mechanisms. Several these processes (e.g. gly­ cosylation, methylation, phosphorylation) because their obvious in-