Quantitative Predictions of a Noncarrier Model for Glucose Transport across the Human Red Blood Cell Membrane

摘要: There is an increasing amount of experimental data on transport across biological membranes which cannot be readily accommodated by classical mobile carrier models. We propose models for membrane based upon current concepts in molecular enzymology, the component involved oligomeric protein undergoes substrate-induced conformational changes. A number paradoxical observations glucose human erythrocyte are explained if a tetramer possessing two classes binding sites with different affinities glucose. develop detail particular model this type, internal transfer model, occurs substrate from one subunit to another protein. The fit predictions most very good. Those fitted accounted any presently available model. extend our qualitatively include sodium-activated cotransport systems sugars and amino acids.