Calcification in Aortic Stenosis

摘要: Aortic stenosis is a common, potentially fatal condition that set to become an increasing public health burden. Once symptoms develop, there inexorable deterioration with poor prognosis. Despite this, are no medical therapies capable of modifying disease progression, and the only available treatment aortic valve replacement, which not all patients suited. Conventional teaching suggests degenerative whereby "wear tear" leads calcium deposition within valve. Although mechanical stress injury important factors, it is becoming increasingly appreciated instead governed by highly complex, regulated pathological process similarities skeletal bone formation. This review discusses pathophysiology emphasis on emerging importance calcification, how this can be visualized monitored using noninvasive imaging, our improved knowledge may ultimately translate into novel disease-modifying treatments.