Lower gray matter density and functional connectivity in the anterior insula in smokers compared with never smokers

摘要: Although nicotine addiction is characterized by both structural and functional abnormalities in brain networks involved salience cognitive control, few studies have integrated these data to understand how may support addiction. This study aimed (1) evaluate gray matter density connectivity of the anterior insula cigarette smokers never (2) characterize differences measures were related smoking behavior. We compared magnetic resonance imaging (MRI) (gray via voxel-based morphometry) seed-based MRI 16 minimally deprived matched smokers. Compared with controls, had lower left extending into inferior frontal temporal cortex. Gray this region was inversely correlated cigarettes smoked per day. Smokers exhibited negative (anti-correlation) between regions control (left lPFC) semantic processing/emotion regulation (lateral cortex), whereas controls positive regions. There insula, a central brain's network, when comparing volumetric Volumetric data, but not also associated an aspect behavior (daily smoked).