Modulation of a competitive N-methyl-D-aspartate receptor antagonist binding by zinc oxide.
作者： Pramod S. Terse , Harold L. Komiskey
DOI: 10.1016/S0006-8993(96)01204-8
关键词:
摘要: Zinc through a zinc binding site is known to modulate the of agonists at NMDA receptor. In present study, ability oxide alter specific [3H]CGP-39653, competitive receptor antagonist, was determined in homogenate rat brain tissue. Analysis saturation experiments indicated that significantly increased Kd without changing Bmax [3H]CGP-39653 binding. Furthermore, effect ZnO on glutamate and glycine displacement determined. The results study decreases
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