P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide
作者： Lei Zhang , Tung-Ping Su , Kwang Choi , Webster Maree , Cheng-Ta Li
DOI: 10.1016/J.JPSYCHIRES.2010.08.012
关键词:
摘要: Although suicide represents 1.8% of the global burden disease, there are few objective assays for risk. Being associated with depressive disorders, which have a high risk suicide, proteins P11, P2RX7, and S100β may be biomarkers suicidal disposition. We measured levels p11 P2RX7 mRNA in peripheral blood mononuclear cells (PBMCs) 26 psychiatric patients (11 attempters, 15 non-attempters) post-traumatic stress disorder (PTSD) major (MDD), 14 normal controls, using quantitative real-time PCR. also conducted meta-analysis microarray data p11, from post-mortem prefrontal cortex (PFC) who committed (n = 56) non-suicide controls 61). found that PBMC were significantly lower attempters higher non-attempters, when compared to controls. The PFC completers than (adjusted p 0.007). Unlike all including completers. In addition, did not differ between These results suggest potential adjunctive biomarker assessment mental disorders warrants larger translational study determine its clinical utility.
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