Does vitamin D protect against DNA damage

摘要: Vitamin D is a secosteroid best known for its role in maintaining bone and muscle health. Adequate levels of vitamin may also be beneficial DNA integrity. This can divided into primary function that prevents damage from secondary regulates the growth rate cells. The potential to reduce oxidative human has been suggested by clinical trial where supplementation reduced 8-hydroxy-2'-deoxyguanosine, marker damage, colorectal epithelial crypt Studies animal models different cell types have shown marked reduction stress chromosomal aberrations, prevention telomere shortening inhibition telomerase activity following treatment with D. preventing includes regulation poly-ADP-ribose polymerase response pathway involved detection lesions. It able regulate cycle prevent propagation damaged DNA, apoptosis promote death. contribute cancer, though there little evidence suggest mediates this effect, if real. Very limited data mean intake required minimise remains uncertain.