Gene regulation by SINES and inosines: biological consequences of A-to-I editing of Alu element inverted repeats.

作者: Ling-Ling Chen , Gordon G. Carmichael

DOI: 10.4161/CC.7.21.6927

关键词:

摘要: The Alu elements are conserved approximately 300 nucleotide long repeat sequences that belong to the SINE family of retrotransposons found abundantly in primate genomes. Although vast majority appear be genetically inert, it has been tempting consider great them as "junk DNA." However, a growing line evidence suggests transcribed RNAs fact functionally involved number diverse biological processes. Pairs inverted repeats RNA can form duplex structures lead A-to-I editing by ADAR enzymes. In this review we discuss possible effects editing, with particular focus on regulation gene expression 3'-UTR regions mRNAs.

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