MIF-I's differential actions as an opiate antagonist.
作者： Abba J. Kastin , Richard D. Olson , Rudolph H. Ehrensing , Matthew C. Berzas , Andrew V. Schally
DOI: 10.1016/0091-3057(79)90270-3
关键词:
摘要: The effects of MIF-I (Pro-Leu-Gly-NH2) were examined in three experimental conditions which the opiate antagonist naloxone is active. was found to block analgesic enkephalins and also morphine tail-flick test but not vas deferens assay. Unlike naloxone, did seem reduce food intake VMH-lesioned rats. results suggest possibility that may represent a class naturally occurring antagonists with varying activities independent situations.
elsevier.com
sci-hub.se 参考文章(12)
P Cuatrecasas, K J Chang, Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity. Journal of Biological Chemistry. ,vol. 254, pp. 2610- 2618 ,(1979) , 10.1016/S0021-9258(17)30115-1
R E Huppler, P E Gilbert, W R Martin, J A Thompson, C G Eades, The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. Journal of Pharmacology and Experimental Therapeutics. ,vol. 197, pp. 517- 532 ,(1976)
J.M. van Ree, D. de Wied, Prolyl-leucyl-glycinamide (PLG) facilitates morphine dependence Life Sciences. ,vol. 19, pp. 1331- 1339 ,(1976) , 10.1016/0024-3205(76)90430-6
Simon Chiu, Ram K. Mishra, Antagonism of morphine-induced catalepsy by L-prolyl-L-leucyl-glycinamide European Journal of Pharmacology. ,vol. 53, pp. 119- 125 ,(1979) , 10.1016/0014-2999(79)90156-0
Bruce M. King, F. Xavier Castellanos, Abba J. Kastin, Matthew C. Berzas, Michael D. Mauk, Gayle A. Olson, Richard D. Olson, Naloxone-induced suppression of food intake in normal and hypothalamic obese rats Pharmacology, Biochemistry and Behavior. ,vol. 11, pp. 729- 732 ,(1979) , 10.1016/0091-3057(79)90272-7
R. Walter, R. F. Ritzmann, H. N. Bhargava, L. B. Flexner, Prolyl-leucyl-glycinamide, cyclo(leucylglycine), and derivatives block development of physical dependence on morphine in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 518- 520 ,(1979) , 10.1073/PNAS.76.1.518
Abba J. Kastin, David H. Coy, Andrew V. Schally, Chester A. Meyers, Activity of VIP, somatostatin and other peptides in the mouse vas deferens assay. Pharmacology, Biochemistry and Behavior. ,vol. 9, pp. 673- 676 ,(1978) , 10.1016/0091-3057(78)90220-4
Kwen-Jen Chang, Eli Hazum, Pedro Cuatrecasas, Multiple opiate receptors Trends in Neurosciences. ,vol. 3, pp. 160- 162 ,(1980) , 10.1016/0166-2236(80)90059-4
Abba J. Kastin, Michael T. Jemison, David H. Coy, Analgesia after peripheral administration of enkephalin and endorphin analogues Pharmacology, Biochemistry and Behavior. ,vol. 11, pp. 713- 716 ,(1979) , 10.1016/0091-3057(79)90268-5
Abba J. Kastin, Richard D. Olson, Andrew V. Schally, David H. Coy, CNS effects of peripherally administered brain peptides. Life Sciences. ,vol. 25, pp. 401- 414 ,(1979) , 10.1016/0024-3205(79)90572-1