Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey

摘要: The nature of proliferative cells in the subgranular zone (SGZ) hippocampal region and fate their progeny was analyzed by 3H- thymidine (3H-TdR) autoradiography combined with immunocytochemistry at light electron microscopic levels 18 rhesus monkeys ranging age from late gestation to 17 years. Our analysis indicates that, during last quarter first 3 postnatal months, SGZ produces both glial neuronal cells. These 2 major classes originate precursor lines and, following mitotic division, migrate granular layer. During juvenile period (4–6 months age), production tapers off most postmitotic remaining within differentiate into elements. In postpubertal animals (3 years older), 3H-TdR- labeled dentate gyrus belong several non-neuronal classes. largest group immunoreactive fibrillary acidic protein (GFAP) levels, indicating astrocytic nature. labeled, GFAP-negative had ultra-structural characteristics either microglia, oligodendroglia, or progenitory stem Therefore, there is a continuing addition and/or turnover sexually mature monkeys, but, contrast massive neurogenesis reported adult rodents, new neurons could not be detected after puberty. significance stable population formation primates discussed relation its possible function memory.