The Effect of Chronic Aspirin Use on Duodenal and Gastric Ulcer Hospitalizations

摘要: Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there little published evidence linking aspirin consumption to duodenal ulcer. The effect of 1 g per day on site-specific ulcer hospitalizations was examined using data from 3-year randomized, double-blind, placebo-controlled trial 4,524 subjects (Aspirin Myocardial Infarction Study). There were 23 and 14 during the follow-up period. All but two verified by endoscopy, radiogram, or biopsy/surgery. For males, Cox-model survival analysis showed that age- smoking-adjusted relative hospitalization 10.7 times higher group than placebo (95% confidence interval, 2.5 45.5; p less 0.0001). adjusted 9.1 1.2 71.4; = 0.04). Due small number females in study, relationship between not analyzed. However, males combined, age-, smoking-, sex-adjusted peptic 7.7 2.7 21.7; We conclude chronic use both females.