Hypoxia and Anaemia Produce Equivalent Effects on Maximal Oxygen Consumption

摘要: In humans, oxygen flows from inspired air to the mitochondria against a resistance, which is overcome by an overall O2 pressure gradient. According conductance equation, this resistance provided sum of numerous in-series resistances, so that progressive drop in partial takes place. This approach was applied study transfer system at maximal exercise (22). case, steady-state, flow same across each and equal Vo2max. Afterwards, multifactorial model Vo2max limitation developed, assuming resistances (or their reciprocal, conductances) provides sizeable fraction Three major groups conductances were identified, namely 1) pulmonary conductances, related alveolar ventilation alveolar-capillary transfer, 2) cardiovascular (Gq), due transport, 3) muscular tissue diffusion utilisation. The second turned out provide 60-to-70% limitation, least during with big muscle normoxia (4, 5, 10).