摘要: Abstract Gap junction channels are formed by paired oligomeric membrane hemichannels called connexons, which composed of proteins the connexin family. Experiments with transfected cell lines and Xenopus oocytes have demonstrated that heterotypic intercellular two each a different connexin, can selectively occur. Studies Stauffer [Stauffer, K. A. (1995) J. Biol. Chem. 270, 6768-6772] shown recombinant Cx26 Cx32 coinfected into insect cells may form heteromeric connexons. By solubilizing subfractionating individual connexons from ovine lenses, we show immunoprecipitation contain connexins forming assemblies in vivo.
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