Major Adverse Kidney Events Are Associated with the Aquaporin 5 -1364A/C Promoter Polymorphism in Sepsis: A Prospective Validation Study.

摘要: Since the functionally important AQP5 -1364A/C single nucleotide promoter polymorphism alters key mechanisms of inflammation and survival in sepsis, it may affect risk an acute kidney injury. Accordingly, we tested hypothesis septic patients that this is associated with major adverse events also validated its impact on 90-day survival. In prospective observational monocentric genetic association study 282 were included genotyped for –1364A/C (rs3759129). The primary endpoint was development within 30 days. AC/CC genotypes, less frequent (41.7%) than AA genotypes (74.3%; OR:0.34; 95%-CI: 0.18–0.62; p < 0.001). Ninety-day (p = 0.004), 94/167 deaths (56.3%) but only 46/115 (40.0%) C-allele carriers. Multiple proportional hazard analysis revealed to be at significantly lower death 90 days (HR: 0.60; 0.42-0.86; 0.006). These findings confirm role as independent prognostic factor sepsis. Furthermore, demonstrate a strong between susceptibility suggesting promising characteristic terms precision medicine.