An Evaluation of Process Variables in wet Granulation
作者： Y. Miyamoto , S. Ogawa , M. Miyajima , H. Stoa , K. Takayama
DOI: 10.3109/03639049509065902
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摘要: AbstractIn wet granulation, determining the process variables which play an essential role in granule quality is crucial for optimizing manufacturing process. An L16(25) fractional factorial experimental design using table of orthogonal arrays was employed order to estimate relative intensity influences five on granulation a high-speed mixer granulator. Total volume and formulation binder solution, blade rotation speed, time, amount powder supplied into granulator were selected as decisive formation granules. Granule yield, geometrical mean size uniformity evaluated representative properties quality. Experimental results analyzed according analysis variance (ANOVA).The significance test contribution ratio ANOVA indicated that, within region, only solution had critical effect on...
informapharmascience.com参考文章(10)
Shigeo Ogawa, Toshihiko Kamijima, Yousuke Miyamoto, Masaharu Miyajima, Hiroshi Sato, Kozo Takayama, Tsuneji Nagai, A New Attempt To Solve the Scale-Up Problem for Granulation Using Response Surface Methodology Journal of Pharmaceutical Sciences. ,vol. 83, pp. 439- 443 ,(1994) , 10.1002/JPS.2600830335
N.-O. Lindberg, C. Jönsson, The Granulation of Lactose and Starch in a Recording High-Speed Mixer, Diosna P25 Drug Development and Industrial Pharmacy. ,vol. 11, pp. 387- 403 ,(1985) , 10.3109/03639048509056877
H. Lindner, P. Kleinebudde, Use of powdered cellulose for the production of pellets by extrusion/spheronization Journal of Pharmacy and Pharmacology. ,vol. 46, pp. 2- 7 ,(2011) , 10.1111/J.2042-7158.1994.TB03710.X
Dale E. Fonner, James R. Buck, Gilbert S. Banker, Mathematical Optimization Techniques in Drug Product Design and Process Analysis Journal of Pharmaceutical Sciences. ,vol. 59, pp. 1587- 1596 ,(1970) , 10.1002/JPS.2600591110
O. Shirakura, M. Yamada, M. Hashimoto, S. Ishimaru, K. Takayama, T. Nagai, Particle Size Design Using Computer Optimization Technique Drug Development and Industrial Pharmacy. ,vol. 17, pp. 471- 483 ,(1991) , 10.3109/03639049109044257
Manabu MATSUMURA, Hiroaki NAKAGAMI, Tadanao YAMAO, Kozo TAKAYAMA, Tsuneji NAGAI, Computer optimization for the formulation of controlled-release theophylline tablet made of micronized low-substituted hydroxypropylcellulose and methylcellulose Chemical & Pharmaceutical Bulletin. ,vol. 42, pp. 1902- 1908 ,(1994) , 10.1248/CPB.42.1902
Kozo TAKAYAMA, Tsuneji NAGAI, Novel computer optimization methodology for pharmaceutical formulations investigated by using sustained-release granules of indomethacin. Chemical & Pharmaceutical Bulletin. ,vol. 37, pp. 160- 167 ,(1989) , 10.1248/CPB.37.160
O. Jungersen, T. Schaefer, H. G. Kristensen, P. Holm, Granulation in high speed mixers. I: Effects of process variables during kneading Pharmazeutische Industrie. ,vol. 45, pp. 806- 811 ,(1983)
A. Jaegerskou, T. Schaefer, H. G. Kristensen, P. Holm, Granulation in high speed mixers. IV: Effect of liquid saturation on the agglomeration Pharmazeutische Industrie. ,vol. 46, pp. 763- 767 ,(1984)
T. Schaefer, H. G. Kristensen, P. Holm, Wet granulation in a laboratory scale high shear mixer Pharmazeutische Industrie. ,vol. 52, pp. 1147- 1153 ,(1990)