Smooth Muscle Relaxants

作者: Charles V. Jackson , John H. McNeill

DOI: 10.1007/978-1-4612-5172-9_5

关键词:

摘要: The term smooth muscle relaxant encompasses a broad spectrum of agents that relax both vascular and non muscle. Therapeutically these relaxants are used for the treatment bronchospastic disorders, premature labor, variety cardiovascular disorders (e.g., hypertension, angina pectoris, peripheral disease, arrhythmias, congestive heart failure). A few have proven to be useful tools investigational purposes, example, xanthines (phosphodiesterase inhibition role cyclic 3′,5′-monophosphate in mediating cellular events) calcium-channel blockers (elucidating calcium normal cell function drug action). This chapter attempts discuss current pharmacodynamics, pharmacokinetics, clinical pharmacology give researcher, clinician, graduate medical student basic information on compounds.

参考文章(83)
D. N. Bateman, D. C. Hobbs, T. M. Twomey, E. A. Stevens, M. D. Rawlins, Prazosin, pharmacokinetics and concentration effect. European Journal of Clinical Pharmacology. ,vol. 16, pp. 177- 181 ,(1979) , 10.1007/BF00562058
H. James Rhodes, M. C. Sutter, The Action of Diazoxide on Isolated Vascular Smooth Muscle Electrophysiology and Contraction Canadian Journal of Physiology and Pharmacology. ,vol. 49, pp. 276- 287 ,(1971) , 10.1139/Y71-030
V. A. W. Kreye, G. D. Baron, J. B. L�th, H. Schmidt-Gayk, Mode of action of sodium nitroprusside on vascular smooth muscle Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 288, pp. 381- 402 ,(1975) , 10.1007/BF00501284
Alfred G. Gilman, George B. Koelle, Alfred Gilman, Louis Sanford Goodman, The pharmacological basis of therapeutics ,(2000)
Uri Elkayam, Thierry H. Lejemtel, Mitlesh Mathur, Hillel S. Ribner, William H. Frishman, Joel Strom, Edmund H. Sonnenblick, Marked early attenuation of hemodynamic effects of oral prazosin therapy in chronic congestive heart failure American Journal of Cardiology. ,vol. 44, pp. 540- 545 ,(1979) , 10.1016/0002-9149(79)90409-0
Charles Z. Naggar, Effects of amyl nitrite on left ventricular relaxation in patients with borderline hypertension American Journal of Cardiology. ,vol. 50, pp. 979- 984 ,(1982) , 10.1016/0002-9149(82)90405-2
G. ROSS, P. V. COLE, Cardiovascular actions of sodium nitroprusside in dogs Anaesthesia. ,vol. 28, pp. 400- 406 ,(1973) , 10.1111/J.1365-2044.1973.TB00488.X
Hirofumi Yasue, Shingo Omote, Akinori Takizawa, Masao Nagao, Kunihisa Miwa, Satoru Tanaka, Exertional angina pectoris caused by coronary arterial spasm: effects of various drugs. American Journal of Cardiology. ,vol. 43, pp. 647- 652 ,(1979) , 10.1016/0002-9149(79)90026-2