Activity intensity, assistive devices and joint replacement influence predicted remodelling in the proximal femur.

摘要: Bone morphology and density changes are commonly observed following joint replacement, may contribute to the risks of implant loosening periprosthetic fracture reduce available bone stock for revision surgery. This study was presented in ‘Bone Cartilage Mechanobiology across scales’ WCCM symposium review development remodelling prediction methods demonstrate simulation adaptive around hip replacement femoral components, incorporating intrinsic (prosthesis) extrinsic (activity loading) factors. An iterative process applied finite element models a femur implanted with cementless total (THR) resurfacing implant. Previously developed cemented THR implant, this modified enabled influence pre- post-operative patient activity loading be evaluated. A control algorithm used identical conditions, predicted extents temporal trends were measured by generating virtual X-rays DXA scans. The improved qualitative quantitative predictions both implants, but demonstrated sensitivity scan region definition appropriate implant–bone position sizing. Predicted intact response changed that simplified model, although effects important, mechanics implantation dominant. supports application predictive as one range physical computational studies, which should conducted preclinical evaluation new prostheses.