Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography.

摘要: The purpose of this work was to develop magnetic resonance elastography (MRE) for the fast and reproducible measurement spatially averaged viscoelastic constants living human brain. technique based on a phase-sensitive echo planar imaging acquisition. Motion encoding orthogonal image plane synchronized intracranial shear vibrations at driving frequencies 25 50 Hz induced by head-rocker actuator. Ten time-resolved phase-difference wave images were recorded within 60 s analyzed stiffness viscosity. Six healthy volunteers (six men; mean age 34.5 years; range 25–44 years) underwent 23–39 follow-up MRE studies over period 6 months. Interindividual mean ± SD moduli viscosities found be 1.17 ± 0.03 kPa 3.1 ± 0.4 Pas 25 Hz 1.56 ± 0.07 kPa 3.4 ± 0.2 Pas 50 Hz, respectively (P ≤ 0.01). intraindividual modulus data 1.01–1.31 kPa (25 Hz) 1.33–1.77 kPa (50 Hz). observed dispersion indicates limited applicability Voigt's model explain behavior brain parenchyma applied frequency range. narrow distribution small confidence intervals demonstrates excellent reproducibility experimental protocol. results are necessary as reference future comparisons between pathological data. Copyright © 2007 John Wiley & Sons, Ltd.