Nuclear factor kappaB signaling in atherogenesis

作者: Menno P.J. de Winther , Edwin Kanters , Georg Kraal , Marten H. Hofker

DOI: 10.1161/01.ATV.0000160340.72641.87

关键词:

摘要: Atherosclerosis is an inflammatory disease, characterized by the accumulation of macrophage-derived foam cells in vessel wall and accompanied production a wide range chemokines, cytokines, growth factors. These factors regulate turnover differentiation immigrating resident cells, eventually influencing plaque development. One key regulators inflammation transcription factor nuclear κB (NF-κB), which, for long time, has been regarded as proatherogenic factor, mainly because its regulation many proinflammatory genes linked to atherosclerosis. NF-κB may play important role guarding delicate balance atherosclerotic process direct regulator anti-inflammatory cell survival proliferation. Here we address recent literature on function responses relation

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