Rate of drug metabolism in obese volunteers before and during starvation and in azotemic patients.

摘要: Abstract The elimination of sulfisoxazole was studied to determine the effects several clinical states on excretion and metabolism drugs. Plasma urine free total were measured at intervals after a 2.0-Gm. intravenous dose. half-life rates drug calculated from these values. Six healthy obese volunteers had range 0.052–0.074 hr. −1 0.028–0.077 . Five during period starvation ketoacidosis which time decreased in all unchanged. Three four patients with azotemia low very for this drug. We conclude that azotemic cannot metabolize some drugs normal rate therefore may require lower than customary doses avoid excessive cumulation.