Serotonin transporter polymorphisms and persistent, pervasive childhood aggression.
作者： Sahar Ehtesham , Danielle Bender , Lidia Baldassarra , Joseph H. Beitchman , Helene Mik
DOI: 10.1176/APPI.AJP.163.6.1103
关键词:
摘要: Objective: The purpose of this study was to examine the potential association serotonin transporter (5-HTT) gene and childhood aggression by testing 5-HTT variable-number-tandem-repeat promoter polymorphism (5-HTTLPR), including recently discovered Lg allelic variant 5-HTTLPR. Method: Clinically referred children displaying extreme aggression, with a minimum 2-year history, were genotyped for 5-HTTLPR (N=77) (N=78). Analyses compared genotype frequencies agressive healthy comparison subjects. Results: “low expressing” genotypic variants (S/S, Lg/S, Lg/Lg) significantly associated aggression. Conclusions: This is first report significant between
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