Robust dual modality antibacterial action using silver-Prussian blue nanoscale coordination polymer

摘要: Abstract We report the synthesis of novel silver-doped Prussian blue nanoscale coordination polymers (SPB NCPs), for dual modality photothermal ablation and oxidative toxicity in bacterial cells. The comparison SPB NCPs (having Fe-CN-Ag bonds) with conventionally used (PB NCPs, having Fe-CN-Fe was investigated terms their physical therapeutic properties. It observed that both PB have similar dimensions, crystalline phase optical Both these showed robust effect by heat generation (hyperthermia) upon exposure to red laser light. However, among two, only NCP oxidase-like activity generating H2O2 aqueous medium, presumably due its silver content. In vitro antibacterial studies revealed but not show inherent towards bacteria an IC50 value close 2.5 μg/ml. can be inferred this is nature, as a result behaviour shown NCPs. Furthermore, light activation resulted substantial additional (photothermal toxicity) cells treated comparison, marginal NCP-treated bacteria. Thus, we conclude combination toxicities demonstrated control makes former promising agents at low dosages.