Immunvermittelte arzneimittelinduzierte Leberschäden
作者： P. Obermayer-Straub , F. Van Pelt , M. P. Manns
DOI: 10.1007/978-3-642-57194-7_45
关键词:
摘要: Leberschaden, die durch direkte Toxizitat eines Arzeneimitteis verursacht werden, sind in erster Linie von den chemischen Eigenschaften des Medikaments selbst abhangig. Die beruht auf der direkten Wechselwirkung Arzneimittels oder seiner reaktiven Metabolite mit Komponenten Zelle, also v, a. Proteinen, DNA und Membranen. Durch kovalentes Binden Radikalen an zellulare Makromolekule werden Schadigungen Storungen zellularen Stoffwechsels verursacht, zur Nekrotisierung Gewebes zum Absterben Zellen Apoptose fuhren.
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