Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches.
作者： Nevine M Hanna , William Waite , Katie Taylor , Woong-Gyu Jung , David Mukai
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摘要: Objective: Hamster cheek pouches (HCP) with various degrees of 9,10-dimethyl-1,2-benzanthracene (DMBA)–induced dysplasia and malignancies were imaged OCT/ODT in vivo vitro to assess the potential for three-dimensional high-resolution optical localization airway malignancy. Background Data: Optical coherence tomography (OCT)/optical doppler (ODT) provide capability real-time (2–20 µm) cross-sectional imaging tissues spatially resolved blood flow microvasculature pathology diagnostics. Methods: DMBA was applied right side pouch (HCP), mineral oil (control) left three times weekly 10–18 weeks Syrian Golden Hamsters using a standard protocol malignancy induction. HCP as well post-excision, prototype 1310-nm broadband superluminescent diode-based device constructed our laboratory. Three-dimensional images constructed, a...
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