Cellular functions of MLL/SET-family histone H3 lysine 4 methyltransferase components

摘要: The MLL/SET family of histone H3 lysine 4 methyltransferases form enzyme complexes with core subunits ASH2L, WDR5, RbBP5, and DPY-30 (often abbreviated WRAD), are responsible for global methylation, a hallmark actively transcribed chromatin in mammalian cells. Accordingly, the function these proteins is required wide variety processes including stem cell differentiation, growth division, body segmentation, hematopoiesis. While most work on MLL-WRAD has focused this complex recent studies indicate that interact other lncRNAs can localize to cellular organelles beyond nucleus. In review, we focus recently described activities interacting partners both inside outside