Accumulation of immunoreactivity to ubiquitin carboxyl-terminal hydrolase PGP 9.5 in axons of human cases with spinal cord lesions

摘要: The protein gene product PGP 9.5 is one of the major polypeptides in neurons. It can act as a ubiquitin carboxyl-terminal hydrolase ubiquitin-mediated degradation proteins. present study was performed to find out if human cases with spinal cord trauma immunohistochemical signs accumulation injured axons known accumulate ubiquitin. For comparison, we used six autopsy without pathology, case syringomyelia, ischaemic injury cord, and ALS cases. Controls presented 9.5-immunostained weak moderate intensity longitudinal tracts. Immunoreactivity not detected nerve cell bodies, glial cells or grey matter. All nine showed axonal swellings, but their numbers varied. Intensely immunostained swellings were particularly abundant survival period up 1 month after trauma. Strongly immunoreactive also infarct syringomyelia. In conclusion, other focal injuries severed possibly resulting from disturbed transport. thus seems be may take part proteins cord.