Recent Developments in the Stereoselective Synthesis of Nitrogen‐Containing Heterocycles using N‐Acylimines as Reactive Substrates

摘要: This report focuses on the utilization of N-acylimines in addition reactions aimed at preparation heterocyclic compounds. These can be directly obtained by reaction with suitable nucleophilic reagents or prepared further elaboration initially formed adducts. The asymmetric synthesis these hetero- and polyheterocyclic derivatives is mostly achieved using chiral catalyzed reactions, including recently introduced enantioselective Biginelli reaction. Applications isatin ketimines to stereoselective biologically active spiroxindole compounds are also reported.