Joint effect of insulin signaling genes on all-cause mortality.
作者： Claudia Menzaghi , Andrea Fontana , Massimiliano Copetti , Stefano Rizza , Belinda Spoto
DOI: 10.1016/J.ATHEROSCLEROSIS.2014.10.005
关键词:
摘要: Abstract Objective : We have previously reported the combined effect of SNPs perturbing insulin signaling ( ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on resistance (IR), type 2 diabetes (T2D) and cardiovascular events. here investigated whether such a affects also all-cause mortality in sample 1851 Whites European ancestry. Methods first 721 patients, 232 deaths, 3389 person-years (py). Replication was assessed two samples patients with T2D: Gargano Mortality Study (GMS) 714 127 5426 py Joslin Kidney (JKS) comprising 416 214 5325 py. Results In sample, individuals carrying 1 or ≥2 risk alleles had 33% p = 0.06) 51% = 0.02) increased mortality, as compared no alleles. A similar, though not significant, trend obtained replication only for subject carrying ≥ 2 pooled analysis, higher rate to those 0 (HR = 1.34, 95%CI = 1.08–1.67; = 0.008), one allele (HR = 1.41, 95%CI = 1.13–1.75; = 0.002). This association independent from several possible confounders including sex, age, BMI, hypertension status. Conclusion Our data suggest that variants affecting exert joint is consistent role abnormal risk.
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