Multidrug resistance-associated protein 2 (MRP2/ABCC2)

摘要: Hereditary MRP2 functional deficiency results in conjugated hyperbilirubinemia, which is an autosomal recessive disorder known as Dubin–Johnson syndrome. Since plays important role the homeostasis of bilirubin and bile salt disposition drugs, disturbance function can result lipid accumulation compounds liver to a toxic level; hence there increasing interest its drug discovery development. The mediated biliary excretion fluoroquinolone antibiotics gives these drugs pharmacological advantage because they are efficiently excreted into followed by enterohepatic recirculation, achieves concentration necessary for treatment inflammatory conditions affecting tract. harbors multiple binding sites displays complex transport kinetics, one group substrates could be stimulated some modulators inhibited others. These factors should taken account when interpreting vitro interaction.