Composite Lymphoma as Co-occurrence of Advanced Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Carrying Trisomy 12 and t(14;18) and Peripheral T-cell Lymphoma.

摘要: Composite lymphoma is defined as the co-occurrence of two types lymphoma, comprising 1-4% lymphomas, and association B-cell-type chronic lymphocytic leukemia (B-CLL)/small peripheral T-cell (PTCL) rare. Here, we report a case (77-year-old woman) advanced B-CLL complicated by newly appearing PTCL. Two years after onset B-CLL, CLL cells acquired CD38 antigen expression disease entity became CLL/prolymphocytic leukemia. Trisomy 12 t(14;18) karyotypes were observed. Five large abnormal with convoluted nuclei appeared in blood rapidly increased number. These positive for CD3, CD4, CD5, CD30 (partially), CD56, αβ-type receptor (TCR), which PCR demonstrated monoclonal TCR-γ gene rearrangement. An additional diagnosis PTCL, not otherwise specified was made. We treated her an R-CHOP regimen, resulting marked reduction but progressive Brentuximab vedotin had transient effect, patient died sepsis due to residual PTCL pancytopenia. This highly informative tumor biology terms emergence both chromosomal abnormalities progression this