Regioselective synthesis of pyrazoles fused with heteroaliphatic amines at the [3,4-c] edges
作者： Sergey P. Ivonin , Bohdan B. Kurpil’ , Dmitry M. Volochnyuk , Oleksandr O. Grygorenko
DOI: 10.1016/J.TETLET.2015.09.108
关键词:
摘要: A regioselective approach to the synthesis of 2,4,5,7-tetrahydropyrrolo[3,4-c]pyrazoles, 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridines and 2,4,5,6,7,8-hexahydropyrazolo[3,4-c]azepines is described. The method relies on annulation saturated heterocyclic amine ring a suitably functionalized trisubstituted pyrazole allows for preparation target bicyclic compounds in five, six eight steps, respectively.
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