Excess of extracolonic non-endometrial multiple primary cancers in MSH2 germline mutation carriers over MLH1.

作者: Kevin M. Lin-Hurtubise , Christopher G. Yheulon , Ronald A. Gagliano , Henry T. Lynch

DOI: 10.1002/JSO.23413

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摘要: Background The lynch syndrome (LS) tumor spectrum involves colorectal cancer (CRC), endometrial (EC), and less frequently various extracolonic non-endometrial cancers (non-EC). The organ-specific survival rates of these patients are well defined, however, the collective all-cancers combined (CRC + EC + non-EC) unclear. Methods Fifty-two MSH2 68 MLH1 were followed for a median 6.3 years after diagnosis first cancer, regardless type. proportions CRC only, EC, non-EC, multiple primary compared between two genotypes. Kaplan–Meier curves developed comparisons. Results MSH2 present with only (37% MSH2, 62% MLH1, P = 0.0096), manifest more (38% 18% P = 0.013), develop (62% 38% P = 0.003), non-EC (46% 24% P = 0.028) carry greater risk urinary tract (UTC) (13.4% 1.5% P = 0.024). There was no difference in 10-year groups (P = 0.4). Conclusion The additional propensity UTC carriers argues favor screening individuals. Other types should be tailored to expression history specific LS mutation. J. Surg. Oncol. 2013; 108:433–437. © 2013 Wiley Periodicals, Inc.

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