Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

作者: Sandrine Caburet , Mikko Anttonen , Anne-Laure Todeschini , Leila Unkila-Kallio , Denis Mestivier

DOI: 10.1186/S12885-015-1283-0

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摘要: Background Ovarian granulosa cell tumors (GCTs) are the most frequent sex cord-stromal tumors. Several studies have shown that a somatic mutation leading to C134W substitution in transcription factor FOXL2 appears more than 95% of adult-type GCTs. Its pervasive presence suggests is main cancer driver gene. However, other mutations and genomic changes might also contribute tumor formation and/or progression.

参考文章(64)
Nathalie East, Abdulaziz Alobaid, Frédéric Goffin, Karim Ouallouche, Philippe Gauthier, Granulosa Cell Tumour: A Recurrence 40 Years After Initial Diagnosis Journal of obstetrics and gynaecology Canada. ,vol. 27, pp. 363- 364 ,(2005) , 10.1016/S1701-2163(16)30464-9
Hae Young Ko, Dong Soo Lee, Soonhag Kim, None, Noninvasive imaging of microRNA124a-mediated repression of the chromosome 14 ORF 24 gene during neurogenesis FEBS Journal. ,vol. 276, pp. 4854- 4865 ,(2009) , 10.1111/J.1742-4658.2009.07185.X
Judith A. Jaehning, The Paf1 complex: Platform or player in RNA polymerase II transcription? Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. ,vol. 1799, pp. 379- 388 ,(2010) , 10.1016/J.BBAGRM.2010.01.001
Stacey Jamieson, Ralf Butzow, Noora Andersson, Maria Alexiadis, Leila Unkila-Kallio, Markku Heikinheimo, Peter J Fuller, Mikko Anttonen, The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary Modern Pathology. ,vol. 23, pp. 1477- 1485 ,(2010) , 10.1038/MODPATHOL.2010.145
D. Pectasides, E. Pectasides, A. Psyrri, Granulosa cell tumor of the ovary Cancer Treatment Reviews. ,vol. 34, pp. 1- 12 ,(2008) , 10.1016/J.CTRV.2007.08.007
Yue-Shan Lin, Hock-Liew Eng, Yee-Jee Jan, Herng-Sheng Lee, William L. Ho, Chiou-Ping Liou, Wen-Yu Lee, Ching-Cherng Tzeng, Molecular cytogenetics of ovarian granulosa cell tumors by comparative genomic hybridization. Gynecologic Oncology. ,vol. 97, pp. 68- 73 ,(2005) , 10.1016/J.YGYNO.2004.12.014
Douglas A. Collins, Harry P.C. Hogenkamp, Michael K. O'Connor, Stephen Naylor, Linda M. Benson, Timothy J. Hardyman, Linda M. Thorson, Biodistribution of radiolabeled adenosylcobalamin in patients diagnosed with various malignancies. Mayo Clinic proceedings. ,vol. 75, pp. 568- 580 ,(2000) , 10.4065/75.6.568
Biljana Culjkovic-Kraljacic, Aurélie Baguet, Laurent Volpon, Abdellatif Amri, Katherine L.B. Borden, The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation Cell Reports. ,vol. 2, pp. 207- 215 ,(2012) , 10.1016/J.CELREP.2012.07.007
Nicolas Moniaux, Christophe Nemos, Shonali Deb, Bing Zhu, Irena Dornreiter, Michael A. Hollingsworth, Surinder K. Batra, The Human RNA Polymerase II-Associated Factor 1 (hPaf1): A New Regulator of Cell-Cycle Progression PLoS ONE. ,vol. 4, pp. e7077- ,(2009) , 10.1371/JOURNAL.PONE.0007077
Jing Huang, Li Zhang, Wei Liu, Qinyuan Liao, Taiping Shi, Lin Xiao, Fanlei Hu, Xiaoyan Qiu, CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest Histochemistry and Cell Biology. ,vol. 138, pp. 41- 55 ,(2012) , 10.1007/S00418-012-0932-5