A multi-centre evaluation of nine rapid, point-of-care syphilis tests using archived sera

摘要: Objectives: To evaluate nine rapid syphilis tests at eight geographically diverse laboratory sites for their performance and operational characteristics. Methods: Tests were compared “head to head” using locally assembled panels of 100 archived (50 positive 50 negative) sera each site as reference standards the Treponema pallidum haemagglutination or T particle agglutination test. In addition inter-site variation, result stability, test reproducibility characteristics assessed. Results: All gave good relative standard with sensitivities ranging from 84.5–97.7% specificities 84.5–98%. Result stability was variable if reading delayed past recommended period. found be easy use, especially lateral flow tests. Conclusions: evaluated have acceptable could make an impact on control syphilis. that can use whole blood do not require refrigeration selected further evaluation in field settings.