Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase
作者： o Chroma Therapeutics Ltd. Needham , o Chroma Therapeutics Ltd. Davidson , Alan Hornsby c , o Chroma Therapeutics Ltd. Drummond , Alan Hastings c
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摘要: Covalent conjugation of an alpha amino acid ester to a modulator the activity target intracellular enzyme or receptor, wherein group conjugate is hydrolysable by one more carboxylesterase enzymes corresponding acid, leads accumulation carboxylic hydrolysis product in cell and enables improved prolonged receptor modulation relative unconjugated modulator.
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