Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

作者: Alexander Seiler , Manuela Schneider , Heidi Förster , Stephan Roth , Eva K Wirth

DOI: 10.1016/J.CMET.2008.07.005

关键词:

摘要: … revealed damaged and pyknotic cells in the pyramidal layer of the CA3 region in GPx4-… -nick-end-labeling)-positive nuclei along the pyramidal cell layer. More specifically, parvalbumin-…

参考文章(33)
Carsten Culmsee, Changlian Zhu, Stefan Landshamer, Barbara Becattini, Ernst Wagner, Maurizio Pellecchia, Klas Blomgren, Nikolaus Plesnila, Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia The Journal of Neuroscience. ,vol. 25, pp. 10262- 10272 ,(2005) , 10.1523/JNEUROSCI.2818-05.2005
Tankred Schewe, Hartmut Kühn, Kerstin Schnurr, Jutta Belkner, Fulvio Ursini, The Selenoenzyme Phospholipid Hydroperoxide Glutathione Peroxidase Controls the Activity of the 15-Lipoxygenase with Complex Substrates and Preserves the Specificity of the Oxygenation Products Journal of Biological Chemistry. ,vol. 271, pp. 4653- 4658 ,(1996) , 10.1074/JBC.271.9.4653
M. Conrad, S. G. Moreno, F. Sinowatz, F. Ursini, S. Kölle, A. Roveri, M. Brielmeier, W. Wurst, M. Maiorino, G. W. Bornkamm, The Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase Is a Protein Thiol Peroxidase Contributing to Sperm Chromatin Stability Molecular and Cellular Biology. ,vol. 25, pp. 7637- 7644 ,(2005) , 10.1128/MCB.25.17.7637-7644.2005
Nazanine Modjtahedi, Fabrizio Giordanetto, Frank Madeo, Guido Kroemer, Apoptosis-inducing factor: vital and lethal Trends in Cell Biology. ,vol. 16, pp. 264- 272 ,(2006) , 10.1016/J.TCB.2006.03.008
Klaus van Leyen, Hahn Young Kim, Seong-Ryong Lee, Guang Jin, Ken Arai, Eng H. Lo, Baicalein and 12/15-Lipoxygenase in the Ischemic Brain Stroke. ,vol. 37, pp. 3014- 3018 ,(2006) , 10.1161/01.STR.0000249004.25444.A5
Nageswara R. Madamanchi, Marschall S. Runge, Mitochondrial dysfunction in atherosclerosis Circulation Research. ,vol. 100, pp. 460- 473 ,(2007) , 10.1161/01.RES.0000258450.44413.96
Michael T. Lin, M. Flint Beal, Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature. ,vol. 443, pp. 787- 795 ,(2006) , 10.1038/NATURE05292
Sandra M. Sendobry, Joseph A. Cornicelli, Kathryn Welch, Thomas Bocan, Bradley Tait, Bharat K. Trivedi, Norman Colbry, Richard D. Dyer, Steven J. Feinmark, Alan Daugherty, Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties British Journal of Pharmacology. ,vol. 120, pp. 1199- 1206 ,(1997) , 10.1038/SJ.BJP.0701007