The Enigmatic Cytokine Oncostatin M and Roles in Disease

摘要: Oncostatin M is a secreted cytokine involved in homeostasis and diseases involving chronic inflammation. It member of the gp130 family cytokines that have pleiotropic functions differentiation, cell proliferation, hematopoetic, immunologic, inflammatory networks. However, also has activities novel to mediators this others may fundamental roles mechanisms inflammation pathology. Studies explored cancer, bone metabolism, liver regeneration, conditions with including rheumatoid arthritis, lung skin disease, atherosclerosis, cardiovascular disease. This paper will review biology historical fashion focus on its unique activities, vitro vivo, differentiate it from other inspire further study or consideration therapeutic approaches.